About this Project
We are developing a Medicago Hapmap as part of an international consortium consisting of the University of Minnesota, the National Center for Genome Resources (NCGR), Boyce Thompson Institute (BTI), J. Craig Venter Institute (JCVI) Hamline University, the University of Southern California, INRA-Montpellier, ENSAT-Toulouse, and the Noble Foundation.
Briefly, 384 inbred lines spanning the range of Medicago diversity are being resequenced using Illumina next generation technology. This provides a foundation for discovering single nucleotide polymorphisms (SNPs), insertions/deletions (INDELs) and copy number variants (CNV) at very high resolution among the Medicago lines. Thirty of these lines have been deeply resequenced (20X coverage or more), while the remainder are sequenced at least 5X coverage. The resulting database of sequence variants establishes a basis for describing population structure and identifying genome segments with shared ancestry (haplotypes) - and thereby creating a long-term, community-accessible genome-wide association (GWA) mapping resource.
Primary funding for the Medicago Hapmap project comes from the Plant Genome Program of the National Science Foundation.
News
June 2014
July 2014
7th International Conference on Legume Genetics and Genomics Congress and 6th International Food Legumes Research Conference (Saskatoon, Canada).
April 2014
Updated SNPs against Mt4.0 now available.
January 2014
Blast search now available against draft R108 sequence.
August 2013
Mt4.0 released by J. Craig Venter Institute.
May 2013
Genome-wide association analysis of Medicago Hapmap published in PLoS ONE
November 2011
Medicago genome sequence published in Nature
October 2011
Medicago sequence diversity published in PNAS
